Hepatitis‐associated aplastic anemia (HAA) is a variant of acquired aplastic anemia (AA) in which immune‐mediated bone marrow failure (BMF) develops following an acute episode of seronegative hepatitis. Dyskeratosis congenita (DC) is an inherited BMF syndrome characterized by the presence of short telomeres, mucocutaneous abnormalities, and cancer predisposition. While both conditions may cause BMF and hepatic […]
Editorial Interstitial Lung Disease by Samantha J. Merck and Mary Armanios October 28, 2016. Over the past decade, it has become evident that abnormally short telomeres are a causal risk factor for pulmonary fibrosis in a large subset of patients. Mutations in the genes that code for the telomerase enzyme essential components are the most […]
Editorial in NEJM by Peter Lansdorp, M.D., Ph.D. May 19, 2016 In a study reported in The New England Journal of Medicine, Townsley et al. found that patients with diseases that are thought to result from defective telomere maintenance benefit from treatment with androgenic anabolic steroids.1 All 12 of the patients they examined had normalization […]
Visit the Dyskeratosis Congenita Outreach at booth 2012 to learn more about Telomere Biology Disorders.
“The large-scale genetic study, conducted at the University of Chicago Medical Center, looked at the link between telomere length and risk for five common cancers. No significant associations between telomere length and other cancer types or subtypes were observed.” The findings were published in Human Molecular Genetics in July, 2015. Read more
“In the clinical setting, flow-FISH was more accurate, reproducible, sensitive, and specific in the measurement of human leukocyte’s telomere length in comparison to qPCR.” Read more
Repeat Diagnostics is happy to sponsor this conference held at the Hospital for Sick Children in Toronto on October 26, 2014.